Pre-implementation genetics for aneuploidy interpretation in PGT-A goals indications and improve infertility outcomes, ART, and how to perform PGT-A

Author(s): Aya Al-Ibraheemi, Mustafa Zakaria, Mohamed Ennaji, Senhaji R. Wassym, Noureddine Louanjli, Mohamed Zarqaoui, Ritu S. Santwani, Nisrine En-Naciri, Hafida Tarik and Romaissa Boutiche

Preimplantation genetic testing for aneuploidy PGT-A has been widely applied today in assisted reproductive technology treatments centers over the world to select the health embryos for transfer with euploid cells and to enhance clinical outcomes such as embryo implantation, clinical pregnancy, and live birth rates. The PGT-A can be performed in during an IVF cycle, after fertilization where a biopsy can be taken from the blastocysts to be genetically tested. PGT-A indication can be to decrease recurrent miscarriage, increase the pregnancy rate in advance maternal age, and increase single embryo transfer. This review also demonstrates new PGT-A method which is called non-invasive PGT-A, to prevent the embryo development distracting and removing extra cells from the embryo, through analyzing leaked DNA.

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